General features and properties of insertion sequence elements

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The S-Transposases

The third transposase family is represented by IS607 which carries a Tpase closely related to serine recombinases such as the resolvases of Tn3 family elements. Little is known about their transposition mechanism. However, it appears likely, in view of the known activities of resolvases (Grindley, 2002), that IS607 transposition may involve a double strand DNA intermediate (Grindley cited as pers. comm. in (Filee, et al., 2007)) see also (Boocock & Rice, 2013) (Fig 1.7.1).

    References :
  • Boocock MR & Rice PA (2013) A proposed mechanism for IS607-family serine transposases. Mob DNA 4: 24.
  • Filee J, Siguier P & Chandler M (2007) Insertion sequence diversity in archaea. Microbiol Mol Biol Rev 71: 121-157.
  • Grindley NDF (2002) The movement of Tn3-like elements: transposition and cointegrate resolution. Mobile DNA II,(Craig NL, Craigie R, Gellert M & Lambowitz A, ed.^eds.), p.^pp. 230-271. ASM press, Washington DC.