Control of transposition activity
Transposition activity is generally maintained at a low level. An often
cited reason for this is that high activities and the accompanying mutagenic
effect of genome rearrangements would be detrimental to the host cell (see (Doolittle, et al., 1984)). Endogenous transposase promoters, in contrast to those
assembled by juxtaposition of -10 and -35 hexamers in those IS families whose
transposition passes through a double-strand circular transposon intermediate,
are generally weak and many are partially located in the terminal IRs. This
would enable their autoregulation by Tpase binding.
WF, Kirkwood TB & Dempster MA (1984) Selfish DNAs with self-restraint
[news].Nature 307: 501-502.